Cell-to-cell variability in organelle abundance reveals mechanisms of organelle biogenesis
نویسندگان
چکیده
منابع مشابه
Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance
Fluctuations in organelle abundance can profoundly limit the precision of cell biological processes from secretion to metabolism. We modeled the dynamics of organelle biogenesis and predicted that organelle abundance fluctuations depend strongly on the specific mechanisms that increase or decrease the number of a given organelle. Our model exactly predicts the size of experimentally measured Go...
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an organism are compared. In mammals, for example, the ER is vastly abundant in exocrine pancreatic secre-where there is no appreciable demand for the secretion of any protein (Bolender, 1974). Using representative examples primarily from the yeast Saccharomyces cere-One hallmark of eukaryotic cells is that they contain visiae, we highlight in this review some recent insights many functionally ...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2019
ISSN: 2470-0045,2470-0053
DOI: 10.1103/physreve.100.022405